PGD/NGS

The couples who are at increased risk for chromosome abnormalities or specific genetic disorders benefit most from PGD/NGS, especially the women who have had several miscarriages, or who have had a prior pregnancy with a chromosome abnormality.
When there is a chance to have a child affected with a specific genetic disease due to a carrier or ill mother and/or father, PGD/ NGS might be planned to identify which embryos are affected, unaffected, or a carrier for that disease.

After embryos are grown for five to six days, the biopsy for PGD/ NGS is done on embryos. Biopsy involves removing a few cells from the trophectoderm, or the layer of cells that is ‘hatching out’ of the embryo at this stage of development. The embryos must be cryopreserved until the PGD test concludes and frozen embryo transfer (FET) cycle is planned for use of healthy embryos. Decisions regarding selection of embryos to transfer into the uterus are made with the advice of both the IVF and genetic specialists.

We recommend PGD/ NGS for:

• Couples who want to know the gender of the embryo which will be transferred
• Women who have habitual miscarriage history
• Couples who have risk to transfer chromosomal abnormalities or monogenic disorders, such as sickle cell disease
• Couples who have lots of failed IVF treatment